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The minimal promoter sequence is linked to the transcribed sequence in a 5′ to 3′ direction by phosphodiester bonds (ie, the promoter is located upstream of the transcribed sequence) to form a contiguous nucleotide sequence.

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Doxycycline hydrochloride is readily and almost completely absorbed from the gastrointestinal tract and absorption is not significantly affected by the presence of food in the stomach or duodenum.